Hudson Soft ended up being a frequent partner with Falcom in the console space, and this Xanadu spin-off for the NES was one of the earliest projects.
The Legend of Heroes began as a one-off, like every other Dragon Slayer entry, but it became its own thing, then grew and grew until it became the series people know Falcom for.
The first of many loosely connected sequels to Dragon Slayer became its own series after exploding on the PC sales charts in a way that
Dragon Slayer was the game, and series, that launched Nihon Falcom to the kind of success that has them still making role-playing games played worldwide, 40 years on.
No, no, I'm Mr. Driller. Dig Dug was my dad.
Known as Battle Mania in Japan, this shooter is short, sweet, and loaded with personality. It's also never been re-released, and wildly expensive.
A sequel to Bubble Bobble that wasn't especially Bubble Bobble-like, to the point that it ended up spinning off into its own series.
You wouldn't know it if you're in North America, but this Bomberman GB is actually the sequel to Bomberman GB.
Sega's competitive-yet-cooperative arcade puzzle game received the Sega Ages treatment, and it's still a great time.
A spin-off of a spin-off where you're ordering other people to go play Final Fantasy.
A jigsaw puzzle of increasing complexity.